Chromatin states define tumour-specific T cell dysfunction and reprogramming.

Philip M, Fairchild L, Sun L, Horste E, Camara S, Shakiba M, Scott A, Lauer P, Viale A, Merghoub T, Hellmann M, Wolchok J, Leslie C, Schietinger ANature. 2017 May 25;545(7655):452-456. 

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https://www.mskcc.org/blog/why-immune-cells-sometimes-fail-fight-cancer-and-what-do-about-it

http://cancerdiscovery.aacrjournals.org/content/early/2017/05/26/2159-8290.CD-RW2017-099

https://www.bioserendipity.com/2017/05/24/understanding-immune-checkpoint-pathways-to-improve-patient-response/

 

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis.

Schietinger A, Philip M, Krisnawan VE, Chiu EY, Delrow JJ, Basom RS, Lauer P, Brockstedt DG, Knoblaugh SE, Hämmerling GJ, Schell TD, Garbi N, Greenberg PD. Immunity. 2016 Aug 8. 10.1016/j.immuni.2016.07.011

 

Beyond Genomics: Multidimensional Analysis of Cancer Therapy Resistance

Philip M, Schietinger ATrends Immunol. 2015 Nov;36(11):665-7.

 

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

Schietinger A, Greenberg PD. Trends Immunol. 2014 Feb;35(2):51-60. PMID: 24210163

 

Rescued tolerant CD8 T cells are preprogrammed to reestablish the tolerant state

Schietinger A, Delrow JJ, Basom RS, Blattman JN, Greenberg PD. Science. 2012 Feb 10;335(6069):723-7.  PMID: 22267581

 

Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer

Schietinger A, Arina A, Liu RB, Wells S, Huang J, Engels B, Bindokas V, Bartkowiak T, Lee D, Herrmann A, Piston DW, Pittet MJ, Lin PC, Zal T, Schreiber H. Oncoimmunology. 2013 Nov 1;2(11):e26677. Epub 2013 Nov 4. PMID: 24482750

 

Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase

Schietinger A, Philip M, Liu RB, Schreiber K, Schreiber H. Journal of Experimental Medicine. 2010 Oct 25;207(11):2469-77. PMID: 20921286

 

A mutant chaperone converts a wild-type protein into a tumor-specific antigen

Schietinger A, Philip M, Yoshida BA, Azadi P, Liu H, Meredith SC, Schreiber H. Science. 2006 Oct 13;314(5797):304-8. PMID: 17038624

 

IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner

Liu RB, Engels B, Schreiber K, Ciszewski C, Schietinger A, Schreiber H, Jabri B. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8158-63. PMID: 23637340

 

Cell-intrinsic abrogation of TGF-β signaling delays but does not prevent dysfunction of self/tumor-specific CD8 T cells in a murine model of autochthonous prostate cancer

Chou CK, Schietinger A, Liggitt HD, Tan X, Funk S, Freeman GJ, Ratliff TL, Greenberg NM, Greenberg PD. Journal of Immunology2012 Oct 15;189(8):3936-46. PMID: 22984076

 

A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs).

Stone JD, Aggen DH, Schietinger A, Schreiber H, Kranz DM. Oncoimmunology. 2012 Sep 1;1(6):863-873. PMID: 23162754

 

Densely granulated murine NK cells eradicate large solid tumors

Liu RB, Engels B, Arina A, Schreiber K, Hyjek E, Schietinger A, Binder DC, Butz E, Krausz T, Rowley DA, Jabri B, Schreiber H. Cancer Research. 2012 Apr 15;72(8):1964-74. PMID: 22374983

 

Ribosomal versus non-ribosomal cellular antigens: factors determining efficiency of indirect presentation to CD4+ T cells

Philip M, Schietinger A, Schreiber H. Immunology. 2010 Aug;130(4):494-503. PMID: 20331471

 

Antibody recognition of a unique tumor-specific glycopeptide antigen

Brooks CL, Schietinger A, Borisova SN, Kufer P, Okon M, Hirama T, Mackenzie CR, Wang LX, Schreiber H, Evans SV. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10056-61. PMID: 20479270

 

Specificity in cancer immunotherapy

Schietinger A, Philip M, Schreiber H. Seminars in Immunology. 2008 Oct;20(5):276-85. PMID: 18684640

 

Equilibrium between host and cancer caused by effector T cells killing tumor stroma

Zhang B, Zhang Y, Bowerman NA, Schietinger A, Fu YX, Kranz DM, Rowley DA, Schreiber H. Cancer Research. 2008 Mar 1;68(5):1563-71. PMID: 18316622

 

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

Zhang B, Bowerman NA, Salama JK, Schmidt H, Spiotto MT, Schietinger A, Yu P, Fu YX, Weichselbaum RR, Rowley DA, Kranz DM, Schreiber H. Journal of Experimental Medicine. 2007 Jan 22;204(1):49-55. PMID: 17210731

 

Priming of naive T cells inside tumors leads to eradication of established tumors

Yu P, Lee Y, Liu W, Chin RK, Wang J, Wang Y, Schietinger A, Philip M, Schreiber H, Fu YX. Nature Immunology. 2004 Feb;5(2):141-9. PMID: 14704792