08.29.2017: Brown S et al Nature 2017 Aug 17;548(7667):334-337. Correction of aberrant growth preserves tissue homeostasis.

08.22.2017: Li HB et al Nature 2017 Aug 17;548(7667):338-342. m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.

08.15.2017: Patel SJ et al Nature 2017 Aug 7. doi: 10.1038/nature23477. [Epub ahead of print]. Identification of essential genes for cancer immunotherapy.

08.08.2017: Manguso RT et al Nature 2017 Jul 27;547(7664):413-418. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

08.01.2017: Wieland D et al Nature Communications 2017 May 3;8:15050. doi: 10.1038/ncomms15050. TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation.

07.22.2017: Araki K et al Nature Immunology 2017 Sep;18(9):1046-1057. Translation is actively regulated during the differentiation of CD8+ effector T cells.

07.18.2017: Ghoneim HE et al Cell Jun 29;170(1):142-157.e19. De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation

Short summer break. Will be back in July!

06.06.2017: Mendoza A Nature. 2017 Jun 1;546(7656):158-161. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

05.30.2017: Stevanovic S Science. 2017 Apr 14;356(6334):200-205. Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer.

05.23.2017: Mognol GP PNAS. 2017 Mar 28;114(13):E2776-E2785. Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells.

05.16.2017: Gray SM Immunity. 2017 Apr 18;46(4):596-608. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency.

05.09.2017: Kakaradov B Nat. Immunology.  2017 Apr;18(4):422-432.  Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing.

04.25.2017: Malik BT Science Immunology.  eaam6346 (2017).  Resident memory T cell in the skin mediate durable immunity to melanoma.

02.21.2017: Spitzer MH Cell. 2017 Jan 26;168(3):487-502. Systemic Immunity Is Required for Effective Cancer Immunotherapy


01.31.2017: Fernandez-Ruiz D Immunity. 2016 Oct 18;45(4):889-902. Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

01.24.2017: Borroto A Science Translational Medicine. 2016 Dec 21;370(8):370ra184. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. 

01.17.2017: Phan AT Immunity. 2016 Nov 15;45(5), p1024–1037. Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection

HAPPY NEW YEAR! 2017 -- To another year with exciting JCs!!!!

12.13.2016: Stubbington MJ Nat. Methods. 2016 Apr;13(4):329-32. T cell fate and clonality inference from single-cell transcriptomes.

12.06.2016: Muschaweck A et alJ Exp Med 2016 Dec 12;213(13):3075-3086 Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells.

11/29/2016: Landsberg J et alNature 2012 Oct 18;490(7420):412-6. Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.

11.08.2016: Ozga AJ et alJ Exp Med 2016 Oct 31. pii: jem.20160206. [Epub ahead of print] pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion.

11.01.2016: Moynihan et alNature Medicine 2016 Oct 24. doi: 10.1038/nm.4200. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.

10.25.2016: Eil R et alNature 2016 Sep 14; doi 10.1038/nature19364 [Epub ahead of print]. Ionic immune suppression within the tumour microenvironment limits T cell effector function.

10.18.2016: Textor A et alJ Exp Med 2016 Oct 17;213(11):2333-2348. Epub 2016 Oct 3. Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.

10.11.2016: Saito et al, Nature Medicine 2016 June;22(6);679-84. doi: 10.1038/nm.4086. Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.

10.04.2016: Wong MT et al, Immunity 2016 Aug 16;45(2):442-56. doi: 10.1016/j.immuni.2016.07.007. A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

09.13.2016: Singer M et alCell 2016 Sep 8;166(6):1500-1511 A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.

09.06.2016: Riedel A et alNature Immunology 2016 Sep; 17(9):1118-27 Tumor-induced stromal reprogramming drives lymph node transformation

The Schietinger Lab Journal Club takes a brief summer break and resumes in September. See you again soon....

08.16.2016: Chu HH et alImmunity 2016 Jul 19;45(1):159-71 Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population.

08.09.2016: Im SJ et alNature 2016 August 2; doi: 10.1038/nature19330 [Epub ahead of print] Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.

08.02.2016: Utzschneider DT et alJournal of Experimental Medicine 2016 Jul 25. High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival

07.26.2016: Ellebrect CT et alScience 2016 Jul 8;353(6295):179-84. Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease.

07.19.2016: Posey AD et alImmunity  2016 Jun 21;44(6):1444-54. Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.

07.12.2016: Cuylen S et alNature  2016 June 29. doi:10.1038/nature18610 [Epub ahead of print]  Ki-67 acts as a biological surfactant to disperse mitotic chromosomes.

07.05.2016: Khan TN et alJournal of Experimental Medicine 2016 May 30;213(6):951-66.[Epub ahead of print] Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection.

06.21.2016: Xing S et alNature Immunology  2016 June 17(6):695-73. Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.

06.14.2016: Lau L et alScience  2015 Oct 30;350(6260):568-71. DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway.

06.07.2016: Ho SS et alImmunity 2016 May 17. 44(5):1177-89. The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells.

05.31.2016: Delconte RB et alNature Immunology 2016 May 23. dot: 10.1038/ni.3470. CIS is a potent checkpoint in NK cell-mediated tumor immunity.

05.22.2016: Malladi S et alCell 2016 March 24. 165(1):45-60. Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

05.17.2016: Roychoudhuri R et alNature Immunology 2016 May 9. doi: 10.1038/ni.3441. BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers.

05.10.2016: Verbist KC et alNature 2016 April 21. 532(7599):389-93. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.

05.03.2016: Salmon H et alImmunity 2016 April 19. 44(4):924-38. Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.

04.26.2016: Tirosh I et alScience 2016 April 8. 352(6282):189-96. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.

04.04.2017: Juneja VR et al, J Exp Med 2017 Apr 3;214(4):895-904. doi: 10.1084. PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.

03.22.2016: Yang W et alNature 2016 March 16. doi:10.1038/nature17412. Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism.

03.08.2016: Peng W et alCancer Discovery 2016 Feb;6(2):202-16. Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.

03.01.2016: Gros A et alNature Medicine 2016 Feb 22.doi: 10.1038/nm.4051. Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients.

02.23.2016: Russ BE et alImmunity 2014 Nov 20;41(5):853-65. Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8(+) T cell differentiation.

02.16.2016: Malandro N et al, Immunity 2016 Jan 19;44(1):179-93. Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.

01.19.2016: Gaublomme, JT, et al., Cell 2015 Dec 3;163(6):1400-12. Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.

01.12.2016: Klebanoff, CA, et al., J Clin Invest 2016 Jan 4. Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.

01.05.2016: Palmer, D. C., et al. J Exp Med (2015). 212(12): 2095-2113. Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.

12.01.2015: Vetizou, M., et al., Science 2015 Nov 27. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.

11.24.2015: Braumueller H.,  et al., Nature 2013 Feb 21;494(7437):361-5. T-helper-1-cell cytokines drive cancer into senescence.

11.17.2015: Peng D,  et al., Nature 2015 Nov 12;527(7577):249-53. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.

11.10.2015: Gross A,  et al., J Clin Invest. 2014 May;124(5):2246-59. PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.

11.03.2015: Zehn D,  et al., J Immunol 2010 Jun 1;184(11):6320-6. Lack of original antigenic sin in recall CD8(+) T cell responses.

10.13.2015: Wu, C. Y.,  et al., Science 2015 Sep 24. pii: aab4077. [Epub ahead of print]. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.

10.05.2015: Twyman-Saint Victor C et al., Nature 2015 Apr 16;520(7547):373-7. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.

09.29.2015: Martinez et al., Immunity 42, 265-278 The Transcription Factor NFAT Promotes Exhaustion of activated CD8 T cells